Physiology Behind Signs and Symptoms of Snakebite (2)

[Bite assumed to be inflicted by common tiger snake, therefore not all physiological explanations will apply to other species of snakes]

 

Paired fang marks or a single mark or scratch may be seen

          Entry site; redness (also other cardinal signs) caused by localised affects of immune system, e.g. mobilisation of WBC’s

Headache; nausea and vomiting; confusion and collapse

          Can sometimes be attributed to fear, i.e. psychologically induced

          Interruption of post-synaptic neurotoxins (as characterised by the rapid onset of this symptom, <1hr)

Dizziness and blurred vision

          Can sometimes be attributed to fear

Abdominal cramps and pain

          Procoagulant activity – leading to widespread clot formation/debrinogenation

Difficulty in speaking, swallowing or breathing; facial or limb weakness and paralysis; fitting, and loss of consciousness

          Potent pre-synaptic neurotoxins (have negative effect on membrane proteins, such as ion channels)

          Myotoxins, affect skeletal muscle causing loss of control (i.e. the muscles usually under conscious control)

Respiratory and/or cardiac arrest

          Procoagulant activity – leading to widespread clot formation/defibrination

          Potent pre-synaptic neurotoxins (have negative effect on membrane proteins, such as ion channels)

          Myotoxins, affect skeletal muscle causing loss of control (i.e. the muscles usually under conscious control)  

 

 

References

http://www.avru.org/compendium/biogs/A000084b.htm

http://gorp.away.com/gorp/health/snakefaq15.htm

http://en.wikipedia.org/wiki/Neurotoxin

http://www.usyd.edu.au/anaes/venom/snakebite.html

Lecture 15: Envenomation and the neuromuscular junction (W. Hodgson)

Advertisements

~ by pcl4 on July 24, 2008.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

w

Connecting to %s

 
%d bloggers like this: